12,018 research outputs found
Fabrication process of a high temperature polymer matrix engine duct
The process that was used in the molding of an advanced composite outer by-pass duct planned for the F404 engine is discussed. This duct was developed as a potential replacement for the existing titanium duct in order to reduce both the weight and cost of the duct. The composite duct is now going into the manufacturing technology portion of the program. The duct is fabricated using graphite cloth impregnated with the PMR-15 matrix system
Hydration and mobility of HO-(aq)
The hydroxide anion plays an essential role in many chemical and biochemical
reactions. But a molecular-scale description of its hydration state, and hence
also its transport, in water is currently controversial. The statistical
mechanical quasi-chemical theory of solutions suggests that HO[H2O]3- is the
predominant species in the aqueous phase under standard conditions. This result
is in close agreement with recent spectroscopic studies on hydroxide water
clusters, and with the available thermodynamic hydration free energies. In
contrast, a recent ab initio molecular dynamics simulation has suggested that
HO[H_2O]4- is the only dominant aqueous solution species. We apply adiabatic ab
initio molecular dynamics simulations, and find good agreement with both the
quasi-chemical theoretical predictions and experimental results. The present
results suggest a picture that is simpler, more traditional, but with
additional subtlety. These coordination structures are labile but the
tri-coordinate species is the prominent case. This conclusion is unaltered with
changes in the electronic density functional. No evidence is found for
rate-determining activated inter-conversion of a HO[H2O]4- trap structure to
HO[H2O]3-, mediating hydroxide transport. The view of HO- diffusion as the
hopping of a proton hole has substantial validity, the rate depending largely
on the dynamic disorder of the water hydrogen-bond network.Comment: 7 pages, 5 figures, additional results include
Tsunamis, Viscosity and the HBT Puzzle
The equation of state and bulk and shear viscosities are shown to be able to
affect the transverse dynamics of a central heavy ion collision. The net
entropy, along with the femtoscopic radii are shown to be affected at the
10-20% level by both shear and bulk viscosity. The degree to which these
effects help build a tsunami-like pulse is also discussed.Comment: Contribution to SQM 2007 in Levoca, Slovaki
Towards the 3D-Imaging of Sources
Geometric details of a nuclear reaction zone, at the time of particle
emission, can be restored from low relative-velocity particle-correlations,
following imaging. Some of the source details get erased and are a potential
cause of problems in the imaging, in the form of instabilities. These can be
coped with by following the method of discretized optimization for the restored
sources. So far it has been possible to produce 1-dimensional emission source
images, corresponding to the reactions averaged over all possible spatial
directions. Currently, efforts are in progress to restore angular details.Comment: Talk given at the Int. Workshop on Hot and Dense Matter in
Relativistic Heavy Ion Collisions, March 24-27, 2004, Budapest; 10 pages, 6
figure
Hydrogen Dissociation and Diffusion on Ni and Ti -doped Mg(0001) Surfaces
It is well known, both theoretically and experimentally, that alloying
MgH with transition elements can significantly improve the thermodynamic
and kinetic properties for H desorption, as well as the H intake by Mg
bulk. Here we present a density functional theory investigation of hydrogen
dissociation and surface diffusion over Ni-doped surface, and compare the
findings to previously investigated Ti-doped Mg(0001) and pure Mg(0001)
surfaces. Our results show that the energy barrier for hydrogen dissociation on
the pure Mg(0001) surface is high, while it is small/null when Ni/Ti are added
to the surface as dopants. We find that the binding energy of the two H atoms
near the dissociation site is high on Ti, effectively impeding diffusion away
from the Ti site. By contrast, we find that on Ni the energy barrier for
diffusion is much reduced. Therefore, although both Ti and Ni promote H
dissociation, only Ni appears to be a good catalyst for Mg hydrogenation,
allowing diffusion away from the catalytic sites. Experimental results
corroborate these theoretical findings, i.e. faster hydrogenation of the Ni
doped Mg sample as opposed to the reference Mg or Ti doped Mg.Comment: 17 pages, 15 figures, to appear in Journal of Chemical Physic
Final state interactions in two-particle interferometry
We reconsider the influence of two-particle final state interactions (FSI) on
two-particle Bose-Einstein interferometry. We concentrate in particular on the
problem of particle emission at different times. Assuming chaoticity of the
source, we derive a new general expression for the symmetrized two-particle
cross section. We discuss the approximations needed to derive from the general
result the Koonin-Pratt formula. Introducing a less stringent version of the
so-called smoothness approximation we also derive a more accurate formula. It
can be implemented into classical event generators and allows to calculate FSI
corrected two-particle correlation functions via modified Bose-Einstein
"weights".Comment: 12 pages RevTeX, 2 ps-figures included, submitted to Phys. Rev.
Introducing First Year Medical Students to Personalized Medicine Concepts in a Small Group Activity
Presented as a Poster Presentation at 2020 IUSM Education Day.An individuals’ genetic profile is becomingly an increasingly important parameter in healthcare decisions. This small group activity was developed to introduce first year medical students in the Molecules to Cells and Tissues course to the concept and significance of Pharmacogenomics and personalized medicine. Additionally, this activity provided students with an opportunity to work with a large dataset and use the information to impact clinical decision making. This activity has two cases, takes student groups approximately 2 hours to complete, and requires internet access. Case materials are available through the learning management system Canvas, and include open-ended questions to guide students through the cases. In these cases students explore the functional significance of different alleles of a panel of cytochrome P450 genes. The group activity has the students examine a large data set of cytochrome P450 genes and cognate alleles to determine their prevalence in the local population and calculate the individuals’ gene scores. The students are then asked to explain the impact of the genotype (or gene score) on the resulting patient phenotype (i.e. the functional significance of the genotype). The first case involves a breast cancer survivor support group in which patients taking Taxol discuss lack of adequate pain relief from opioids and the potential impact of concomitant use of natural compounds/supplements on drug metabolism. The second case involves a patient presenting with recurrent stroke-like symptoms despite being on the anticoagulant medication clopidogrel. The patient is initially suspected to be non-compliant, but is later determined to be a poor metabolizer of the anticoagulant clopidogrelto its active form thus decreasing its efficacy. The expertise of the IUSM Medical Genetics research faculty was leveraged to provide a large data set of cytochrome P450 genes and cognate alleles. The selection of cytochrome P450 was based upon delivering content focused on the biochemistry of the enzyme system and provided an opportunity to highlight the drug interaction database available through IUSM Clinical Pharmacology (The FlockhartTable™ ; https://drug-interactions.medicine.iu.edu/). The addition of natural compounds was to draw students’ attention to the Natural Medicines database, which is the recommended source for evidence-based data on complementary and alternative medicine. Natural Medicines is available through the Ruth Lilly Medical Library and can be searched by substance or condition. It provides both a summary of the literature available on substances as well as the level of evidence or quality of studies done on the substance
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